The digestive system is the most important immunological organ. The role of intestinal flora in immune mechanisms is extremely important as it is an integral part of the inherent immune system, it stimulates acquired immunity and forms the acquired immune response. Therefore, today, there is a special interest in products that, based on scientific evidence, can modulate the mechanisms of the inherent immunity.
One such product is a combination of AHCC® and BB-12® probiotic. AHCC® is a mixture of substances in which the major polysaccharide is alpha-glucan, specifically acetylated 1,4-glucan (the rest are proteins, lipids, carbohydrates and small amounts of beta-glucans). It is produced from the mycelium of Lentinula edodes mushroom (Shiitake) cultivated in a liquid medium containing rice straw. Immunomodulatory activity was clinically proven through increased activity of NK cells in immunocompromised individuals, increased number and activity of dendritic cells, increased proliferation of macrophages that play a key role in primary immunity, and increased cytokine response.
Probiotics are live microorganisms that have a positive effect on the health of the host at a sufficient concentration, and they are a natural part of the physiological flora and have no side effects. The strains of microorganisms acting as probiotics belong to the genus Lactobacillus, Bifidobacterium and Saccharomyces. When ingested in sufficient quantities, they colonize the digestive mucosa where they can manifest their benefits. The role of probiotics in immunomodulation is based on mechanisms involving the synthesis of antimicrobials, the fight against pathogens for nutrients, the modification of toxins and the stimulation of non-specific immunological reactions to pathogens. Numerous large systemic examinations found that probiotics are an effective way of preventing and alleviating the problems with many pathological conditions in children, and they are referred to in guidelines as a fundamental part of therapy and prevention of acute diarrhoea.